Technical Data
138654
GIPC (PDZ Domain-containing Protein GIPC2)
Description:
GIPC, GAIP interacting protein at the C-terminus, is a PDZ domain containing protein that interacts with RGS-GAIP. GIPC was also identified as TIP-2, a protein that interacts with the viral oncoprotein TAX, which transactivates viral and cellular promoters through interactions with various transcription factors. GIPC specifically localizes to clusters of vesicles near the plasma membrane and participates in G protein-coupled signaling pathway involved in regulating clathrin-coated vesicular trafficking. GIPC also associates with membrane bound semaphorin F (M-SemF), which is involved in neuronal axon growth, and it appears to regulate the subcellular distribution of M-SemF in the brain.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.

Hybridoma:
Mouse F0 myeloma cells with spleen cells from Balb/c mice.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG1,k13L1Purified
SizeStorageShippingSourceHost
50ul-20CBlue IceHumanMouse
Concentration:
~1mg/ml
Immunogen:
Recombinant protein corresponding to aa1-315 from human GIPC at C-terminal, expressed in E.coli.
Purity:
Purified
Form
Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
Specificity:
Recognizes human GIPC2.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. De Vries L., et al. (1998). Proc Natl Acad Sci U S A 95(21): 123405. 2. Liu, T F; Kandala G, Setaluri V (2001). J. Biol. Chem. (United States) 276(38): 3576877. 3. Hu, Liaoyuan A., et al. (2003). J. Biol. Chem. (United States) 278(28): 26295301.