Technical Data
144202
ARRB1 (ARRB1, ARR1, Beta-arrestin-1, Arrestin beta-1)
Description:
Arrestin, beta 1, also known asARRB1, is a protein which in humans is encoded by the ARRB1 gene. Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. By fluorescence in situ hybridization,this gene is mapped to 11q13.4. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions.

UniProt Number:
P49407

Gene ID:
ARRB1

Applications:
Suitable for use in Western Blot and Immunohistochemistry (Paraffin).

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Handling:
Store at -20 C for one year. After reconstitution, store at 4 C for one month. Can also be aliquoted and stored frozen at -20 C for long term.
Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug4C/-20CBlue IceHumanRabbit
Concentration:
~1mg/ml
Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminal of human ARRB1, identical to the related rat and mouse sequences.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity:
Recognizes human, mouse and rat ARRB1. No crossreactivity with other proteins.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Buchanan, F. G., Gorden, D. L., Matta, P., Shi, Q., Matrisian, L. M., DuBois, R. N. Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. Proc. Nat. Acad. Sci. 103: 1492-1497, 2006.
2. Nelson, C. D., Perry, S. J., Regier, D. S., Prescott, S. M., Topham, M. K., Lefkowitz, R. J.Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science 315: 663-666, 2007.