Technical Data
A0002-90
ALLM, Calpain Inhibitor II, Ac-LLM-CHO (N-Acetyl-Leu-Leu-Methional)
5mg
Biochemicals Storage: -20°CShipping: Blue Ice
A cell-permeable inhibitor of calpain 1 (Ki =120nM) and calpain 2 (Ki =230nM). Also potently inhibits cathepsin B (Ki =100nM), and cathepsin L (Ki=0.6nM). Shown to induce caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin’s Lymphoma cells.

Sequence:
N-Acetyl-Leu-Leu-Methional

Solubility:
DMSO (25mg/ml) or EtOH (25mg/ml)

Molecular Weight:
~401.57

Storage and Stability:
Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

CAS Number:
136632-32-1

Molecular Formula:
C H N O S

Molecular Weight:
~401.57
Purity: ~95% (HPLC)
Concentration: Not determined
Form: Supplied as a powder.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. ZU, D.-M., and Uckun, F. M. Clin. Cancer Res. 6, 2456-2463.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.