Technical Data
A0004-01
ABC A1 (ATP-binding Cassette (ABC) Tansporter 1)
Description:
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) are associated with Tangier disease (TD). TD is an autosomal recessive disorder results from an absence of
plasma HDL, cholesterol ester depositing in the reticulo- endothelial system and disorders in cellular lipid trafficking. It is expressed on the plasma membrane and the Golgi complex,
and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.

Applications:
Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
MabIgG17i4Purified
SizeStorageShippingSourceHost
100ug4C (-20C Glycerol)Blue IceHumanMouse
Concentration:
~1mg/ml
Immunogen:
Synthetic peptide from human ABC A1 containing amino acids 1800-2260.
Purity:
Purified.
Form
Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
Specificity:
Recognizes human ABCA1. Species Crossreactivity: mouse and chicken.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.