		Technical Data
A0004-01F	ABCB6, CT (ATP-binding Cassette Sub-family B Member 6, Mitochondrial, Mitochondrial ABC Transporter 3, Mt-ABC Transporter 3, Ubiquitously-expressed Mammalian ABC Half Transporter, P-glycoprotein-related Protein, MTABC3, PRP, UMAT)

Description:
The membrane-associated protein ABCB6 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.

Applications:
Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Human	Rabbit

Concentration:

~0.25mg/ml

Immunogen:

Synthetic peptide selected from the C-terminal region of human ABCB6 (KLH).

Purity:

Purified by Protein G affinity chromatography.

Form

Supplied as a liquid in PBS, 0.09% sodium azide.

Specificity:

Recognizes human ABCB6.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Mitsuhashi, N., et al., J. Biol. Chem. 275(23):17536-17540 (2000). 2. Furuya, K.N., et al., Cancer Res. 57(17):3708-3716 (1997). 3. Allikmets, R., et al., Hum. Mol. Genet. 5(10):1649-1655 (1996).