		Technical Data
A0004-01H	ABCB7, CT (ATP-binding Cassette Sub-family B Member 7, Mitochondrial, ATP-binding Cassette Transporter 7, ABC Transporter 7 Protein, ABC7)

Description:
The membrane-associated protein ABCB7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.

Applications:
Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
200ul		-20°C	Blue Ice	Human	Rabbit

Concentration:

~0.25mg/ml

Immunogen:

Synthetic peptide selected from the C-terminal region of human ABCB7 (KLH).

Purity:

Purified by Protein G affinity chromatography.

Form

Supplied as a liquid in PBS, 0.09% sodium azide.

Specificity:

Recognizes human ABCB7.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Allikmets, R., et al., Hum. Mol. Genet. 8(5):743-749 (1999). 2. Csere, P., et al., FEBS Lett. 441(2):266-270 (1998). 3. Mao, M., et al., Proc. Natl. Acad. Sci. USA 95(14):8175-8180 (1998). 4. Shimada, Y., et al., J. Hum. Genet. 43(2):115-122 (1998). 5. Savary, S., et al., Genomics 41(2):275-278 (1997).