Technical Data
A0004-02J
ABCA1 (ATP-binding Cassette Sub-family A Member 1, ATP-binding Cassette Transporter 1, ABC-1, ATP-binding Cassette 1, Cholesterol Efflux Regulatory Protein, ABC1, CERP)
Description:
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) are associated with Tangier disease (TD). TD is an autosomal recessive disorder results from an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and disorders in cellular lipid trafficking. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.

Applications:
Suitable for use in ELISA, Western Blot, Immunoprecipitation, and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 3-6ug/ml
Western Blot: 1:1,000-1:2,000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG110K91Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceMouse
Concentration:
~1mg/ml
Immunogen:
Synthetic peptide corresponding to aa1800-2260.
Purity:
Purified.
Form
Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
Specificity:
Recognizes ABCA1.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.