Technical Data
A0007-34M
Abi-2 (ABI2, SSH3BP2, argBPIB, Abl interactor 2)
Description:
Abl-interactor (Abi) proteins are targets of Abl-family nonreceptor tyrosine kinases and are required for Rac-dependent cytoskeletal reorganization in response to growth factor stimulation (1). Abi-2 acts in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. This protein is involved in cytoskeletal reorganization, and it regulates ABL1/c-Abl-mediated phosphorylation of MENA (2).

Applications:
Suitable for use in Western Blot, Immunocytochemistry and Immunohistochemistry. Other applications have not been tested.

Recommended Dilutions:
Western Blot: 1:1000-1:10,000
Immunohistochemistry: 1:100-1:250
Immunocytochemistry: 1:100-1:250
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
TypeIsotypeCloneGrade
MabEPR7069Supernatant
SizeStorageShippingSourceHost
100ul-20°CBlue IceHumanRabbit
Concentration:
Not determined
Immunogen:
Saynthetic peptide corresponding to residues in human Abi-2.
Purity:
Supernatant
Form
Supplied as a liquid in PBS, pH 7.2, 0.05% BSA, 0.01% sodium azide, 50% glycerol.
Specificity:
Recognizes human Abi-2. Species crossreactivity: Mouse, rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Courtney KD, et al. Mol Cell Neurosci 16(3):244-57, 2000 2. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 38:D190-D195 (2010)