Technical Data
A0578-10
Acid Sensitive Ion Channel Beta (ASICb)
Description:
Two proton-gated channels, acid-sensing ionic channel (ASIC) and dorsal root ASIC (DRASIC), are known to be expressed by sensory neurons. These types of channels are of interest because low pH causes pain. ASIC Beta, a splice variant of ASIC, is found only in a subset of small and large diameter sensory neurons and is absent from sympathetic neurons or the central nervous system.

Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry: 1:500
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
50ul4C (-20C Glycerol)Blue IceRatGuinea pig
Concentration:
Not Determined
Immunogen:
Synthetic peptide, aa3 -18 AGSELDEGDDSPRDLV corresponding to the N-terminus of rat ASICb.
Purity:
Serum
Form
Supplied as a liquid, 0.05% sodium azide, before the addition of glycerol to 40%.
Specificity:
Recognizes rat Acid Sensitive Ion Channel Beta.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Chen, C.C., England, S., Akopian, A.N., Wood, J.N., (1998) A sensory neuron-specific, proton-gated ion channel. PNAS 95: 10240-5.