Technical Data
A0725-02U
ACRP30 (Adipocyte Complement-related Protein of 30kD, Adiponectin, 30kD Adipocyte Complement-related Protein, Adipocyte, C1q and Collagen Domain-containing Protein, Adipose Most Abundant Gene Transcript 1 Protein, AdipoQ, apM1, Gelatin Binding Protein 28,
Description:
Adiponectin, also termed gelatin-binding protein-28 (GBP28), AdipoQ, ACP30 (Acrp30), or apM, is a major adipocyte-secreted adipokine which abundantly present in the circulation as three distinct oligomeric complexes: LMW (67kD), MMW (167kD) and HMW (300kD) adiponectin. Its levels are decreased in insulin resistant, diabetes and cardiovascular disease. Conversely, elevation of circulating adiponectin concentrations can alleviate various vascular dysfunctions in animal models, suggesting this adipokine exerts vasculoprotective effects. In addition, adiponectin may also be of importance in the development and progression of several malignancies.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG10K93Affinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanMouse
Concentration:
As reported
Immunogen:
HEK-293 derived recombinant human adiponectin.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS.
Specificity:
Recognizes human Adiponectin.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Xu A, et al. (2005) Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J. Biol. Chem. 280, 1807318080 2. Xu A, et al. (2008) Selective Elevation of Adiponectin Production by the Natural Compounds Derived from a Medicinal Herb Alleviates Insulin Resistance and Glucose Intolerance in Obese Mice. Endocrinology. [Epub ahead of print] 3. Xu A, et al. (2004) Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice. Endocrinology. 145(2):487-94 4. Wang Y, et al. (2008) Post-translational modifications of adiponectin: mechanisms and functional implications. Biochem J. 409(3):623-33