Technical Data
A0725-18C
Acrp30 (30kD Adipocyte Complement-related Protein, ACDC, Adipocyte C1q and Collagen Domain Containing Protein, Adiponectin, ADPN, ADIPOQ, Adipose Most Abundant Gene Transcript 1 Protein, ADIPQTL1, APM1, apM-1, Gelatin-binding Protein, GBP28)
Description:
Adiponectin is a multimeric adipocyte-specific secretory protein that regulates energy homeostasis, lipid metabolism, and insulin sensitivity with direct anti-diabetic, anti-atherogenic and anti-inflammatory properties. Adiponectin predominantly inhibits proliferation of myelomonocytic lineage cells and is an important negative regulator in hematopoiesis and immune systems. Adiponectin is reported to possibly function as an endogenous factor involved in lipid catabolism and storage or whole body metabolism. It is decreased in obesity and has been demonstrated to inhibit tumor necrosis factor-alpha (TNF-alpha)-induced expression of endothelial adhesion molecules. Adiponectin modulates the inflammatory response of endothelial cells, possibly through cross talk between cAMP-PKA and NF-kappaB signaling pathways.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Hybridization:
Sp2/0 myeloma Isotype: IgG1 cells with spleen cells from BALB/c mice.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG2a10J4Affinity Purified
SizeStorageShippingSourceHost
1mg-20CBlue IceHumanMouse
Concentration:
As reported
Immunogen:
Native human adiponectin
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
Specificity:
Recognizes human serum Adiponectin.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.