Actinomycin D (Streptomyces antibioticus, Dactinomycin, Actinomycin IV, Actinomycin C1)
|Biochemicals||Storage: 4°CShipping: RT|
Suitable for use in nucleic acid inhibition. Actinomycin D inhibits the proliferation of cells in a cell-cycle nonspecific way by forming a stable complex with DNA (via deoxyguanosine residues), thus inhibiting DNA-primed RNA synthesis. It is used in cell culture as a selection agent.
Chemical Name: 2-Amino-(N,N)-1-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1]-[1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
Appearance: Orange to red-brown crystaline powder
Identity: Conforms to USP reference
Specific Rotation:-292 to -317º
Heavy Metals: <0.001%
Loss on Drying: 5%
DNase: None Detected
Protease: None Detected
Residue on Ignition: 0.1%
Working concentration: 0.01 to 2ug/ml
Solublility: Dimethyl sulfoxide (DMSO) 1mg/ml
Light and moisture sensitive.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.