Technical Data
A0850
Actinomycin D (Streptomyces antibioticus, Dactinomycin, Actinomycin IV, Actinomycin C1)
25mg
100mg
500mg
Biochemicals Storage: 4°CShipping: RT
Suitable for use in nucleic acid inhibition. Actinomycin D inhibits the proliferation of cells in a cell-cycle nonspecific way by forming a stable complex with DNA (via deoxyguanosine residues), thus inhibiting DNA-primed RNA synthesis. It is used in cell culture as a selection agent.

Chemical Name: 2-Amino-(N,N)-1-bis(hexadecahydro-6­,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentao­xo-1H-pyrrolo[2,1]-[1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-ox­o-3H-phenoxazine-1,9-dicarboxamide

Purity: 95%
Appearance: Orange to red-brown crystaline powder
Identity: Conforms to USP reference
Potency: 900u/mg
Specific Rotation:-292 to -317º
Heavy Metals: <0.001%
Loss on Drying: 5%
RNase:None Detected
DNase: None Detected
Protease: None Detected
Residue on Ignition: 0.1%
Endotoxin: 100EU/mg
Working concentration: 0.01 to 2ug/ml
Solublility: Dimethyl sulfoxide (DMSO) 1mg/ml
Light and moisture sensitive.

CAS Number:
50-76-0

Molecular Formula:
C62H86N12O16

Molecular Weight:
1255.43
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
US Biological application reference: Nelson, S.A. et al., (2000) Gene 253:87-93. 1. Merck Index, 11:441, #2804 (1989). 2. Meienhofer, J., J. Amer. Chem Soc., 92:3771 (1970). 3. United States Pharmacopoeia, XXII:379 (1990). 4. Singh, A.P.,et al., Can. J. Microbiol.,18 (6), 909 (1972).

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.