Technical Data
A0856-05F
Activin Receptor Type IIA (Activin Receptor Type-2A, Activin Receptor Type IIA, ACTR-IIA, ACTRIIA, ACVR2A, ACVR2) (APC)
Description:
Activin isoforms and other members of the TGF-B superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine threonine kinase receptor, both of which are essential for signal transduction. To date, seven type I and five type II receptors, including the two type I and the two type II activin receptors, designated ActRI(A), ActRIB, ActRII(A) and ActRIIB, have been cloned from mammals. Activin type II receptors are highly conserved. Human, mouse and rat type II activin receptors share greater than 98% aa sequence homology. Recombinant soluble activin type II receptors bind activin with high affinity, and are potent activin antagonists.

Applications:
Suitable for use in Flow Cytometry. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Excitation: 620-650nm

Emission: 660-670nm

Storage and Stability:
May be stored at 4C before opening. DO NOT FREEZE! Stable at 4C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. APC is light sensitive.
TypeIsotypeCloneGrade
MabIgG2A12K5Affinity Purified
SizeStorageShippingSourceHost
100Tests4C Do Not FreezeBlue IceHumanMouse
Concentration:
Not determined
Immunogen:
Recombinant corresponding to human Activin Receptor IIA extracellular domain expressed in SF-21 cells.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).
Specificity:
Recognizes human Activin RIIA.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Attisano, L. et al. (1996) Mol. Cell. Biol. 16:1066. 2. Woodruff, T.K. (1998) Biochem. Pharmacology 55:953.