		Technical Data
A0859-35B	ADAM 17, CT (A Disintegrin And Metalloproteinase 17, TNF-a Converting Enzyme, TACE, TNF alpha Converting Enzyme, CD156b)

Description:
ADAM-17, which is also known as CD156b, is expressed in a wide range of cells in culture. Its biological role is to convert the transmembrane trimeric form of TNF alpha to the soluble form. CD156 is also reported to process a number of other proteins, including L-selectin and TNF p75 receptor.

Applications:
Suitable for use in Western Blot. Other applications have not been tested.

Recommended Dilutions:
Western Blot: 1:500
Optimal dilutions to be determined by researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. m

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Human	Rabbit

Concentration:

~0.5mg/ml

Immunogen:

Peptide corresponding to aa 807-823 of human CD156b

Purity:

Purified by affinity chromatography.

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

Specificity:

Recognizes the C-terminal region of the TNF alpha converting enzyme (TACE), designated CD156b at the 6th leukocyte typing workshop. TACE is a membrane-bound metalloprotease disintegrin which belongs to the mammalian ADAM family.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Moss, M. L. et al. (1997). Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor - alpha. Nature. 385: 733-736