Technical Data
A0906-65
ADRA2B, ID (Alpha-2B Adrenergic Receptor, Alpha-2B Adrenoreceptor, Alpha-2B Adrenoceptor, Alpha-2BAR, Alpha-2 Adrenergic Receptor Subtype C2, ADRA2L1, ADRA2RL1)
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Technical Data |
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A0906-65 |
ADRA2B, ID (Alpha-2B Adrenergic Receptor, Alpha-2B Adrenoreceptor, Alpha-2B Adrenoceptor, Alpha-2BAR, Alpha-2 Adrenergic Receptor Subtype C2, ADRA2L1, ADRA2RL1) |
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Description: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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