Technical Data
Aggrecan (Aggrecan Core Protein, ACAN, AGCAN, Aggrecan 1, Aggrecan1, AGC 1, AGC1, AGC1 Protein, Antigen Identified by Monoclonal A0122, Cartilage Specific Proteoglycan Core Protein, CSPCP, CSPGCP, Chondroitin Sulfate Proteoglycan 1, Chondroitin Sulfate Pr
Aggrecan is a proteoglycan and member of the aggrecan/versican proteoglycan family, which forms a major component of the extracellular matrix (ECM) of both cartilage and the central nervous system (CNS). Studies using a panel of core protein-directed antibodies against human aggrecan, revealed the distribution of different aggrecan isoforms within the CNS, and sub-divided the isoforms into clusters 1-5 accordingly. These studies also showed a difference in the relative abundance of these isoforms when comparing brain and cartilage tissues.

Suitable for use in ELISA, Immunofluorescence, Immunohistochemistry and Western Blot. Other applications not tested.

Recommended Dilutions:
Immunohistochemistry: Paraffin sections
Optimal dilutions to be determined by the researcher.

NS1 myeloma cells with spleen cells from Balb/c mice.

Immunohistochemistry Positive Control:
Cerebral cortex

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
2ml-20CBlue IceHumanMouse
Not Determined
Purified human articular cartilage aggrecan
Supplied as a liquid in PBS, 0.09% sodium azide.
Recognizes human aggrecan Does not react with bovine, chicken, fish or rat
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Virgintino, D. et al. (2009) Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex.J Cell Mol Med. 13: 3151-73.