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Technical Data |
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A1059-53E |
Aggrecan (Proteoglycan, PG, AGC 1, Aggrecan 1, Antigen Identified By Monoclonal A0122, Cartilage Specific Proteoglycan Core Protein, Chondroitin Sulfate Proteoglycan Core Protein 1, CSPCP, CSPG1, CSPGCP, Large Aggregating Proteoglycan, MSK16, SEDK) |
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Description: Aggrecan is a proteoglycan and member of the aggrecan/versican proteoglycan family, which forms a major component of the extracellular matrix (ECM) of both cartilage and the central nervous system (CNS). Studies using a panel of core protein-directed antibodies against human aggrecan, revealed the distribution of different aggrecan isoforms within the CNS, and sub-divided the isoforms into clusters 1-5 accordingly. These studies also showed a difference in the relative abundance of these isoforms when comparing brain and cartilage tissues. Applications: Suitable for use in Immunohistochemistry, ELISA, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Immunohistochemistry: Frozen and paraffin sections. Optimal working dilutions to be determined by researcher. Recommended Secondary Reagents: I1904-19C: IgG, F(ab’)2 (HRP) Pab Gt x Mo Positive Control: Cerebral Cortex Hybridoma: NS1 myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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