Technical Data
A1059-87R
AIP, Recombinant, Human, aa1-330, His-Tag (aryl hydrocarbon receptor interacting protein, ARA9, FKBP16, FKBP37, XAP2, HBV-X associated protein, aryl hydrocarbon receptor-interacting protein)
100ug
Molecular Biology Storage: -20CShipping: Blue Ice
Aryl hydrocarbon receptor (AHR) interacting protein, also known as AIP, may play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. It is a Cellular negative regulator of the hepatitis B virus (HBV) X protein. Also, AIP is a ubiquitously expressed protein, binds to HSP 90 and AHR through a highly conserved carboxy-terminal tetraticopeptide repeat domain. Purified by using conventional chromatography techniques.

Recombinant protein corresponding to aa1-330 of human AIP, fused to His-tag at the N-terminal, expressed in E. coli (AAI04828).

Amino Acid Sequence:
MGSSHHHHHH SSGLVPRGSH MADIIARLRE DGIQKRVIQE GRGELPDFQD GTKATFHYRT LHSDDEGTVL DDSRARGKPM ELIIGKKFKL PVWETIVCTM REGEIAQFLC DIKHVVLYPL VAKSLRNIAV GKDPLEGQRH CCGVAQMREH SSLGHADLDA LQQNPQPLIF HMEMLKVESP
GTYQQDPWAM TDEEKAKAVP LIHQEGNRLY REGHVKEAAA KYYDAIACLK NLQMKEQPGS PEWIQLDKQI TPLLLNYCQC KLVVEEYYEV LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQEAQADFAK VLELDPALAP VVSRELRALE ARIRQKDEED KARFRGIFSH

Molecular Weight:
~39.8kD (350aa), confirmed by MALDI-TOF

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight:
~39.8kD
Source: E. coli
Purity: ~90% (SDS-PAGE)
Concentration: ~1mg/ml
Form: Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 1mM DTT, 10% glycerol

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Kazlauskas A., et al. (2000) J Biol Chem. 275:41317-41324. Meyer BK., et al. (1998) Mol Cell Biol. 18:978-988.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.