Technical Data
A1210-03
ALAS2, Recombinant, Human (Aminolevulinate delta-Synthase 2, Delta ALA Synthetase)
100ug
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Technical Data |
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A1210-03 |
ALAS2, Recombinant, Human (Aminolevulinate delta-Synthase 2, Delta ALA Synthetase) |
100ug |
| Molecular Biology | Storage: -70°CShipping: Dry Ice |
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ALAS2 specifies an erythroid-specific mitochondrially located enzyme. It catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified. Source: Recombinant human ALAS, aa136-553, with N-terminal His tag, expressed in E. coli. Molecular Weight: 46kD Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months. Molecular Weight: 46kD |
Source: E. coli Purity: 90% Concentration: As reported Form: Supplied as a liquid in 25mM Tris-HCl, pH 8.0, 100mM NaCl, 0.05% Tween-20, 20% glycerol, 3mM DTT, 20uM pyridoxal 5' phosphate monohydrate. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Lee, P.L. et al., Blood Cells Mol. Dis. 36 (2), 292-297 (2006). 2. Astner, I. et al., EMBO J. 24 (18), 3166-3177 (2005).
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