Technical Data
ALAS2, Recombinant, Human (Aminolevulinate delta-Synthase 2, Delta ALA Synthetase)
Molecular Biology Storage: -70CShipping: Dry Ice
ALAS2 specifies an erythroid-specific mitochondrially located enzyme. It catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.

Recombinant human ALAS, aa136-553, with N-terminal His tag, expressed in E. coli.

Molecular Weight: 46kD

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
Aliquot to avoid repeated freezing and thawing and store at -70C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.

Molecular Weight:
Source: E. coli
Purity: 90%
Concentration: As reported
Form: Supplied as a liquid in 25mM Tris-HCl, pH 8.0, 100mM NaCl, 0.05% Tween-20, 20% glycerol, 3mM DTT, 20uM pyridoxal 5' phosphate monohydrate.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Lee, P.L. et al., Blood Cells Mol. Dis. 36 (2), 292-297 (2006). 2. Astner, I. et al., EMBO J. 24 (18), 3166-3177 (2005).

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.