Technical Data
Alarin (del/E3, Galanin-like Peptide, GALP) (Carboxyfluorescein)
Alarin is a hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2, and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion. Isoform 2 exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2 (By similarity). Cleavage of the signal peptide generates a peptide of 25 amino acids, termed alarin because of the N-terminal alanine and the C-terminal serine. Involved in ganglionic differentiation in neuroblastic tumor tissues.

Suitable for use in FLISA. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Carboxyfluorescein Labeled product is light sensitive.
100ul-20CBlue IceRatRabbit
Not determined
Synthetic peptide corresponding to rat Alarin.
Supplied as a liquid. Labeled with Carboxyfluorescein.
Recognizes rat Alarin.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
General References:
1. Ohtaki T., Kumano S., Ishibashi Y., Ogi K., Matsui H., Harada M., Kitada C., Kurokawa T., Onda H., Fujino M.; "Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus."; J. Biol. Chem. 274:37041-37045(1999).
2. Kofler B., Moritz K., Fenninger K.; "Differential splicing leads to the novel peptide alarin another member of the galanin-like peptide family."
3. Santic R., Fenninger K., Graf K., Schneider R., Hauser-Kronberger C., Schilling F.H., Kogner P., Ratschek M., Jones N., Sperl W., Kofler B.; "Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide gene."; J. Mol. Neurosci. 29:145-152(2006).
4. Santic R., Schmidhuber S.M., Lang R., Rauch I., Voglas E., Eberhard N., Bauer J.W., Brain S.D., Kofler B.; "Alarin is a vasoactive peptide."; Proc. Natl. Acad. Sci. U.S.A. 104:10217-10222(2007).