Technical Data
A1378-25C
ATIC (Bifunctional Purine Biosynthesis Protein PURH, Phosphoribosylaminoimidazole carboxamide Formyltransferase, 5-aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase, AICAR Transformylase, IMP Cyclohydrolase, Inosinicase, IMP Synthetase, OK/SW-
Description:
ATIC (AICAR transformylase/IMP cyclohydrolase) belongs to the purH family, expressed in the cytoplasm, predicted molecular weight approximately 65kD. ATIC catalyzes the penultimate and final steps in the de novo purine nucleotide biosynthesis pathway. ATIC acts as a bifunctional enzyme catalyze the formation of FAICAR and IMP. AICA-ribosiduria is a recently discovered inherited metabolic disease caused by a defect in final steps of purine de novo biosynthesis.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 5-10ug/5ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG1,kF38P7H9Affinity Purified
SizeStorageShippingSourceHost
25ug-20CBlue IceMouse
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide AHTNLRLFHH conjugated to Ovalbumin.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Recognizes ATIC. Species Crossreactivity: human, mouse, rat, frog and drosophila.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Rayl EA, et al. 1996. J. Biol. Chem. 271:2225.