Technical Data
A2220
Amphotericin B USP (Fungizone, Fungilin, Ampho-Moronal)
1g
10g
25g
100g
Biochemicals Storage: 4CShipping: RT
Amphotericin B is a polyene antifungal agent for yeast, mold and mycoplasma. It was first isolated by Gold, et a., from Streptomyces nodosus in 1955. It is an amphoteric compound composed of a hydrophilic polyhydroxyl chain along one side and a lipophilic polyene hydrocarbon chain on the other. Amphotericin B is poorly soluble in water. Amphotericin B binds to sterols, preferentially to the primary fungal cell membrane sterol, ergosterol. This binding disrupts osmotic integrity of the fungal membrane, resulting in leakage of intracellular potassium, magnesium, sugars, and metabolites and then cellular death.

Used in the preparation of baculoviral stocks.

Appearance:
Yellow to orange, crystalline powder

Identification (FAB/MS):
Conforms to reference

Solubility:
Soluble in DMSO and DMF/HCl
Amphotericin B is poorly soluble in water.

Potentcy:
750ug/mg

Loss on Drying:
5.0%

Residue upon Ignition:
0.5%

Endotoxin:
2Eu/mg

Storage:
Store at 4C. Light sensitive.

Meets or exceeds USP specifications.

CAS Number:
1397-89-3

Molecular Formula:
C47H73NO17

Molecular Weight:
924.09
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Ausubel, F. M., et al., Current Protocols in Molecular Biology, John Wiley (1992) 2. Maniatis, T., et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press (1989)

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.