		Technical Data
A2275-71V	APBA1, ID (Amyloid beta A4 Precursor Protein-binding Family A Member 1, Neuron-specific X11 Protein, Neuronal Munc18-1-interacting Protein 1, Mint-1, Adapter Protein X11alpha, X11, MINT1)

Description:
APBA1 is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This protein is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Human	Rabbit

Concentration:

~0.25mg/ml

Immunogen:

Synthetic peptide selected from the Center region of human APBA1 (KLH).

Purity:

Purified by ammonium sulfate precipitation.

Form

Supplied as a liquid in PBS, 0.09% sodium azide.

Specificity:

Recognizes human APBA1.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1.van der Geer,P. et.al., Trends Biochem. Sci. 20(7), 277-280 (1995) 2.Xie,Z., et.al., J. Biol. Chem. 280(15), 15413-15421 (2005) 3.Jacobs,E.H., et.al., Neuroscience 138(2), 511-522 (2006)