Technical Data
A2275-74F
-Amyloid, 1-42
1mg
Molecular Biology Storage: -20°CShipping: Blue Ice
Major constituent of plaques and tangles that occur in Alzheimer’s disease (AD) patients

See A2275-74F1 for antisense, inactive peptide.

Sequence (linear): H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH

Amino Acid Analysis: Confirms expected sequence

Storage and Stability:
Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.





Molecular Formula:
C203H311N55O60S

Molecular Weight:
4514.10
Source: Synthetic
Purity: ~80-90% by HPLC analysis
Concentration: As reported
Form: Supplied as a lyophilized powder.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Borchelt, D.R. et. al. (1997) Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19: 939-945. 2. Arendash, G.W. et al. (1999) Intravascular b-amyloid infusion increases blood pressure: implications for a vasoactive role of b-amyloid in the pathogenesis of Alzheimer’s disease. Neuroscience Letters 268:17-20. 3. Yan, S.D. et al. (1999) Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Ab-induced cytotoxicity. J. Biol. Chem. 274:2145-2156. 4. Bradt, B.M. et al. (1999) Complement-dependent proinflammatory properties of the Alzheimer’s disease b-peptide. J. Exp. Med. 188:431-438. 5. Eisenhauer, P.B. et al. (2000) Toxicity of various amyloid beta peptide species in cultured human blood-brain barrier endothelial cells: increased toxicity of dutch-type mutant. J. Neurosci. Res. 60(6):804-810.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.