Technical Data
A2275-87N
APPBP1, CT (NEDD8-activating Enzyme E1 Regulatory Subunit, Amyloid Protein-binding Protein 1, Amyloid beta Precursor Protein-binding Protein 1, 59kD, APP-BP1, Proto-oncogene Protein 1, NAE1, HPP1)
Description:
APPBP1 binds to the beta-amyloid precursor protein, a cell surface protein with signal-transducing properties thought to play a role in the pathogenesis of Alzheimer's disease. In addition, this protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. APPB1 is required for cell cycle progression through the S/M checkpoint.

Applications:
Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide selected from the C-terminal region of human APPBP1 (KLH).
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity:
Recognizes human APPBP1.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1.Chen,Y., J. Cell Biol. 163(1), 27-33 (2003). 2.Chen,Y., J. Neurochem. 85(3), 801-809 (2003). 3.Walden,H., Nature 422(6929), 330-334 (2003). 4.Chow,N., J. Biol. Chem. 271(19), 11339-11346 (1996).