		Technical Data
A2294-07A	Angiostatin

Description:
Angiostatin is a proteolytic fragment that comprises the first four kringle domains of the ~85kD plasminogen. Angiostatin reduces endothelial cell proliferation and acts as an
potent inhibitor of angiogenesis and tumor growth.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilutions:
Western Blot: 2ug/ml. Detects a 50kD protein representing recombinant human angiostatin.
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Mouse	Rabbit

Concentration:

~1mg/ml

Immunogen:

Synthetic peptide corresponding to aa1-19, VYLSECKTGIGNGYRGTMS of mouse angiostatin. Species sequence homology: rat, 95%

Purity:

Purified

Form

Supplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide

Specificity:

Recognizes recombinant mouse angiostatin. Species crossreactivity: human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Sim BK et al. Angiostatin and endostatin: endogenous inhibitors of tumor growth. Cancer Metastasis Rev 19:181-90 (2000). 2. Drixler TA et al. Angiogenesis and surgery: from mice to man. Eur J Surg 166:435-46 (2000).