Technical Data
Angiotensin II Type 1 Receptor, Rat (AT1) Control Peptide
Molecular Biology Storage: -20CShipping: Blue Ice
A 10 amino acid peptide sequence mapping near the N-terminus of rat AT II.

Angiotensin II mediates its action by interacting with membrane receptor, Angiotensin II type 1 receptors. The signal is transmitted via G-proteins that activates a phosphatidylinositol-calcium second messenger system. ATII receptors are integral membrane proteins of approx.359-363aa and predicted to contain at least 7 transmembrane domains. The N and C-terminus are predicted to extracellular and cytoplasmic, respectively. Three isoforms of ATII receptors have been cloned. In rat type 1a (359 aa) is expressed in the liver kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal and vascular smooth muscles (1). Rat Type 1b (also known as AT3; 359 aa) is found in liver, kidney, and aorta (2). Type 1c (177 aa) has been detected in brain, kidney, liver, spleen and lung (3.
Source: Rat synthetic peptide
Purity: Highly purified
Concentration: 1 mg/ml
Form: 1mg/ml soln. in PBS, pH 7.4 and 0.1% sodium azide
Specificity: 100% identical in mouse, rat, human, porcine and rabbit. The sequence is the same in all AT II receptor isoforms (Type 1a, 1b and 1c). It has no sequence homology with other G-protein coupled receptors

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Murphy Tj et al (1991) Nature 351, 233; Iwai N et al (1991) BBRC 177, 299; Langford K et al (1992) BBRC 183, 1025; Sasamura h et al (1992) BBRC 185, 253; Yoshida H et al (1992) BBRC 186, 1042; Mauzy CA et al (1992) BBRC 183, 8; Bergsma DJ et al (1992) BBRC 183, 989 2. Konishi H et al (1992) BBRC 199, 467; Iwai N et al (1992) FEBS Lett. 298, 257; Sandberg K et al (1992) BBRC 183, 1090; Elton TS et al (1992) BBRC 184, 1067 3. Hahn AW et al (1993) BBRC 192, 1260.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.