Technical Data
A2295-11L1
Anguinomycin A (5-Demethyl-leptomycin A, KR 2827A, Antibiotic KR 2827A)
100ug
|
Technical Data |
|
A2295-11L1 |
Anguinomycin A (5-Demethyl-leptomycin A, KR 2827A, Antibiotic KR 2827A) |
100ug |
| Biochemicals | Storage: -20°CShipping: Blue Ice |
|
Anguinomycin A, isolated from a Streptomyces sp., displays nanomolar cytotoxicity to murine P388 leukemia cells. In addition, it shows antitumour activity in mice against murine Lewis lung carcinoma and P388 leukemia. Anguinomycin A is an analogue of Leptomycin B, an inhibitor of nuclear export of proteins. Purity: >95% by HPLC Solubility: Soluble in ethanol or methanol. Ethanol recommended. Unstable in DMSO. Related to: Leptomycin A, Leptomycin B, Kazusamycin A, Kazusamycin B CAS Number: 111278-01-4 Molecular Formula: C31H44O6 Molecular Weight: 512.68 |
Source: Streptomyces sp. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
|
|
1. Anguinomycins C and D, new antitumor antibiotics with selective cytotoxicity against transformed cells. Hayakawa Y. et al. J. Antibiot. 1995, 48, 954. 2. New antitumor antibiotics, anguinomycins A and B. Hayakawa Y. et al. J. Antibiot. 1987, 40, 1349.
|
||