Technical Data
Anguinomycin A (5-Demethyl-leptomycin A, KR 2827A, Antibiotic KR 2827A)
Biochemicals Storage: -20CShipping: Blue Ice
Anguinomycin A, isolated from a Streptomyces sp., displays nanomolar cytotoxicity to murine P388 leukemia cells. In addition, it shows antitumour activity in mice against murine Lewis lung carcinoma and P388 leukemia. Anguinomycin A is an analogue of Leptomycin B, an inhibitor of nuclear export of proteins.

Purity: >95% by HPLC

Solubility: Soluble in ethanol or methanol. Ethanol recommended. Unstable in DMSO.

Related to: Leptomycin A, Leptomycin B, Kazusamycin A, Kazusamycin B

CAS Number:

Molecular Formula:

Molecular Weight:
Source: Streptomyces sp.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Anguinomycins C and D, new antitumor antibiotics with selective cytotoxicity against transformed cells.
Hayakawa Y. et al. J. Antibiot. 1995, 48, 954. 2. New antitumor antibiotics, anguinomycins A and B. Hayakawa Y. et al. J. Antibiot. 1987, 40, 1349.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.