Technical Data
A2296-73A
ANO7 (Anoctamin-7, Dresden Transmembrane Protein of the Prostate, D-TMPP, IPCA-5, New Gene Expressed in Prostate, Prostate Cancer-associated Protein 5, Transmembrane Protein 16G, NGEP, PCANAP5, TMEM16G)
Description:
NGEP is a prostate-specific protein that belongs to the TMEM16 family and consists of TM16H1, TM16H2 and TM16H3 domains. NGEP gene located at human chromosome 2q37.3, is expressed as two splice variants and encodes two different size proteins. The larger (NGEP-L) is derived from 18 exons, encodes a protein that is predicted to contain seven-membrane-spanning regions and is localized to the plasma membrane. The smaller (NGEP-S) is derived from four exons, encodes an intracellular protein and detected in the cytoplasm of the cell. Because of its selective expression in prostate cancer and its presence on the cell surface, NGEP is a promising target for the antibody-based therapies of prostate cancer. The protein also plays an important role in cell-cell interactions.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanRabbit
Concentration:
Not determined.
Immunogen:
Synthetic peptide corresponding to aa827-843 (CRYRAFRDDDGHYSQTY) of human NGEP/D-TMPP.
Purity:
Serum.
Form
Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
Specificity:
Recognizes human ANO7. Species sequence homology: mouse and rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Bera, TK. et al. Proc. Natl. Acad. Sci. U.S.A. 101:3059-3064 (2004). 2. Kiessling, A. et al. Prostate. 64:387-400 (2005). 3. Katoh, M. et al. Int. J. Mol. Med. 14:759 764 (2004).