Technical Data
A2297-39A
Antibiotic UCN-02 (UCN 02)
1mg
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Technical Data |
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A2297-39A |
Antibiotic UCN-02 (UCN 02) |
1mg |
| Biochemicals | Storage: +4°CShipping: Blue Ice |
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UCN-02 is isolated as a minor co-metabolite of high producing staurosporine strains of selected actinomycetes. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms. Purity: >95% by HPLC Solubility: Soluble in ethyl acetate, ethanol, DMF or DMSO. Related to: Staurosporine, Antibiotic UCN-01 CAS Number: 121569-61-7 Molecular Formula: C28H26N4O4 Molecular Weight: 482.5 |
Source: Streptomyces sp. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. UCN-01-induced cell cycle arrest requires the transcriptional induction of p21waf1/cip1 by activation of mitogen-activated protein/extracellular signal-regulated kinase/extracellular signal-regulated kinase pathway. Facchinetti M.M. et al. Cancer Res. 2004, 64, 3629. 2. UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti- cancer agents for the new century? Akinaga S. et al. Anticancer Drug Des. 2000, 15, 43. 3. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. Takahashi I. et al. J. Antibiot. 1989, 42, 571.
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