Technical Data
A2297-39A
Antibiotic UCN-02 (UCN 02)
1mg
Biochemicals Storage: +4CShipping: Blue Ice
UCN-02 is isolated as a minor co-metabolite of high producing staurosporine strains of selected actinomycetes. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.

Purity: >95% by HPLC

Solubility: Soluble in ethyl acetate, ethanol, DMF or DMSO.

Related to: Staurosporine, Antibiotic UCN-01

CAS Number:
121569-61-7

Molecular Formula:
C28H26N4O4

Molecular Weight:
482.5
Source: Streptomyces sp.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. UCN-01-induced cell cycle arrest requires the transcriptional induction of p21waf1/cip1 by activation of
mitogen-activated protein/extracellular signal-regulated kinase/extracellular signal-regulated kinase
pathway. Facchinetti M.M. et al. Cancer Res. 2004, 64, 3629. 2. UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti- cancer agents for the new century? Akinaga S. et al. Anticancer Drug Des. 2000, 15, 43. 3. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. Takahashi I. et al. J. Antibiot. 1989, 42, 571.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.