Technical Data
A2298-76D1
APG12L (ATG12, Ubiquitin-like Protein ATG12, Autophagy-related Protein 12, APG12-like, APG12)
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Technical Data |
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A2298-76D1 |
APG12L (ATG12, Ubiquitin-like Protein ATG12, Autophagy-related Protein 12, APG12-like, APG12) |
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Description: Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. APG12L is the human homologue of yeast APG12, a ubiquitin-activating enzyme E1-like protein essential for the conjugation system that mediates membrane fusion in autophagy. The protein possesses 27% identity and 48% similarity with the yeast APG12p. Northern blot analysis confirms the ubiquitous expression of the protein in human tissues. The gene encoding human APG12L protein is localized on chromosome 5q21-q22. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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