Technical Data
A2298-79B
Apicidin (cyclo-L-(2-Amino-8-oxodecanoyl)-L- (N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl]Suberoylanilide hydroxamic acid)
1mg
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Technical Data |
|
A2298-79B |
Apicidin (cyclo-L-(2-Amino-8-oxodecanoyl)-L- (N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl]Suberoylanilide hydroxamic acid) |
1mg |
| Biochemicals | Storage: -20°CShipping: Blue Ice |
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A potent, cell permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC50 = 50 – 100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF-10A cells possibly by down regulating MMP-2 in a reversible manner. Applications: Suitable for use as a histone deacetylase inhibitor. Other applications have not been tested Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute with DMSO or ethanol. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. CAS Number: 183506-66-3 Molecular Formula: C34H49N5O6 Molecular Weight: 623.8 |
Purity: ~95% by HPLC Concentration: ~50mg/ml Form: Supplied as an off-white lyophilized powder. Reconstitute in DMSO or ethanol. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Kim, J.S., et al. (2001) Biochem. Biophys. Res. Commun. 281:866. 2. Colletti, L.S., et al. (2001) Bioorg. Med. Chem. Lett. 11:107.
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