Technical Data
AATF (Apoptosis antagonizing transcription factor CHE1, DED, HSPC277, Protein AATF, Rb-binding protein Che-1)
Apoptosis Antagonizing Transcription Factor (AATF), also known as Che-1, is a ubiquitously expressed nuclear protein. Research indicates that AATF functions as a general inhibitor of the histone deacetylase HDAC1. It has been also demonstrated that AATF activates transcription factor E2F and that it is involved in the activation of anti-apoptotic pathways. AATF has been shown to protect neural cells against oxidative damage suggesting it may have therapeutic uses in Alzheimer's Disease.

Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry (paraffin): 2.5ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
Human testis

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
50ug-20CBlue IceHumanRabbit
As reported
Synthetic peptide corresponding to a 12aa sequence near the C-terminus of human AATF.
Purified by ammonium sulfate precipitation.
Supplied as a liquid in PBS, 0.02% sodium azide.
Recognizes human AATF. Species Crossreactivity: mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.