Technical Data
A2299-90W
AATF (Apoptosis antagonizing transcription factor CHE1, DED, HSPC277, Protein AATF, Rb-binding protein Che-1)
Description:
Apoptosis Antagonizing Transcription Factor (AATF), also known as Che-1, is a ubiquitously expressed nuclear protein. Research indicates that AATF functions as a general inhibitor of the histone deacetylase HDAC1. It has been also demonstrated that AATF activates transcription factor E2F and that it is involved in the activation of anti-apoptotic pathways. AATF has been shown to protect neural cells against oxidative damage suggesting it may have therapeutic uses in Alzheimer's Disease.

Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry (paraffin): 2.5ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
Human testis

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabIgGPurified
SizeStorageShippingSourceHost
50ug-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide corresponding to a 12aa sequence near the C-terminus of human AATF.
Purity:
Purified by ammonium sulfate precipitation.
Form
Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity:
Recognizes human AATF. Species Crossreactivity: mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.