Technical Data
A3309-01
ARAP1 (Arf-GAP with Rho-GAP Domain, ANK Repeat and PH Domain-containing Protein 1, Centaurin-delta-2, Cnt-d2, CENTD2, KIAA0782)
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Technical Data |
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A3309-01 |
ARAP1 (Arf-GAP with Rho-GAP Domain, ANK Repeat and PH Domain-containing Protein 1, Centaurin-delta-2, Cnt-d2, CENTD2, KIAA0782) |
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Description: ARAP1 is a 1450aa containing signaling protein, belonging to the centaurin family with SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, ARAP1 displays RHO-GAP and phosphatidylinositol (3, 4, 5) trisphosphate (PIP3)-dependent ARF-GAP activity that regulates ARF-, RHO-, and CDC42-dependent cell activities. It associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thus involved in both signal transduction and cellular trafficking transport of a receptor protein involved in apoptosis. This protein is likely involved in the regulation of the cell-specific trafficking of TNFRSF10A and might thus affect the efficacy of TRAIL-induced apoptosis. ARAP1, an adaptor protein, is ubiquitously expressed in most of the tissues. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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