Technical Data
A3325P
ARC, CT, Blocking Peptide
50ug
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Technical Data |
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A3325P |
ARC, CT, Blocking Peptide |
50ug |
| Molecular Biology | Storage: -20°CShipping: Blue Ice |
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Peptide corresponding to amino acids 191 to 208 of human origin (1). Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and –8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue (1). |
Source: Synthetic peptide Purity: Purified 60-70% Concentration: 0.2mg/ml Form: Supplied as a lyophilized powder. Important Note: This product is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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1. Koseki T, Inohara N, Chen S, Nunez G. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc Natl Acad Sci U S A 1998;95:5156-60
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