Technical Data
A3334-97
ASAP3 (Arf-GAP with SH3 Domain, ANK Repeat and PH Domain-containing Protein 3, Development and Differentiation-enhancing Factor-like 1, Protein Up-regulated in Liver Cancer 1, DDEFL1, UPLC1)
Description:
ASAP3, also known as Development and differentiation-enhancing factor-like 1, is a protein with two ANK repeats, an Arf-GAP domain and a PH domain. ASAP3, an Arf GTPase-activating protein, is implicated in the pathogenesis of hepatocellular carcinoma, and may regulate cell migration associated with the invasion of normal tissue by cancer cells, thus playing an important role in the regulation of GTPase activity. It is known to promote cell proliferation. ASAP3 also has functions nonredundant with ASAP1 to control cell movement and may have a role in cancer cell invasion. ASAP3 is highly expressed in primary hepatocarcinoma and is also detected in lung, liver and blood leukocytes.

Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanRabbit
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to aa693-710 (VISTEPGSDSEEDEEEKR) of human ASAP3.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity:
Recognizes human ASAP3. Species Crossreactivity: chimpanzee. Species sequence homology: equine.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Okabe H. et al. Int. J. Oncol. 24:43-48 (2004). 2. Sjoeblom T. et al. Science. 314:268-274 (2006).