Technical Data
A3550-08D
AVPR1B (AAvpr1b, Arginine Vasopressin Receptor 1B, AVPR3, Antidiuretic Hormone Receptor 1B, Arginine Vasopressin Receptor 3, Pituitary Vasopressin Receptor 3, Vasopressin V1B Receptor; AVPR3, V3/V1b, VIBR, VPR; V3/V1b pituitary vasopressin receptor, VPR3)
Description:
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. AVPR1B expression has been documented in the pituitary, pituitary tumors, pheochromocytoma, breast cancer, and small-cell lung carcinomas.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
ELISA: 1:32,000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20°CBlue IceRatGoat
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to C-KPAGSLKDLEQVD, from the internal region (near C-Terminus) of AVPR1B (NP_036054.1).
Purity:
Purified by affinity chromatography.
Form
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
Specificity:
Recognizes rat AVPR1B. Sequence Homology: mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Dempster EL, Burcescu I, Wigg K, Kiss E, Baji I, Gadoros J, Tamás Z, Kennedy JL, Vetró A, Kovacs M, Barr CL. Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. Arch Gen Psychiatry. 2007 Oct;64(10):1189-95. PMID: 17909131