Technical Data
A3573-60A
AROS (Active Regulator of SIRT1, 40S Ribosomal Protein S19-binding Protein 1, RPS19-binding Protein 1, RPS19BP1, S19BP)
Description:
AROS, a nucleolar protein with an unknown function, interacts with extraribosomal protein RPS19, playing a role in the signaling pathways that regulate rRNA transcription. The deduced aa sequence of AROS, derived from cDNA, defines an isoelectric point of 11.3. No known functional motifs were found in AROS except a short polylysine tract embedded in a putative nucleolar localization signal. At a basal level the protein is expressed ubiquitously with a significantly high level of expression in some tissues. Human AROS gene is mapped to chromosome 22q13.1.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 2-4ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
Human liver

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanRabbit
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to aa1-50 of human AROS.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity:
Recognizes human AROS.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Maeda, N. et al. Biochem. Biophys. Res. Commun. 339:41-46 (2006). 2. Johan, F. et al. Blood. 109:3152-3154 (2007).