Technical Data
A3690
Ascochlorin (Antibiotic LL-Z 1272 gamma)
500ug
Biochemicals Storage: +4CShipping: Blue Ice
The antitumour fungal metabolite ascochlorin specifically inhibits matrix metalloproteinase-9 (MMP9) activity through suppression of activator protein-1 (AP-1) dependent induction of MMP-9 gene expression. Via AP-1 suppression ascochlorin selectively kills MX-1 cells, a human breast cancer cell line lacking estrogen receptors. Ascochlorin also shows activity against Newcastle disease and herpes simplex viruses.

Purity: >95% by HPLC

Solubility: Soluble in ethanol, methanol, DMF or DMSO.

CAS Number:
26166-39-2

Molecular Formula:
C23H29ClO4

Molecular Weight:
404.9
Source: Acremonium sp.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated
gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion
of renal carcinoma cells. Hong S. et al. J. Biol. Chem. 2005, 280, 25202.
2. Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines. Sakaguchi K. et al.
Biochem. Biophys. Res. Commun. 2005, 329, 46.
3. Ascochlorin derivatives as ligands for nuclear hormone receptors. Togashi M. et al. J. Med. Chem. 2003,
46, 4113.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.