Technical Data
A4156-15A
Atrophin 1 (ATN1, DRPLA, Dentatorubral-pallidoluysian Atrophy, NOD)
Description:
Dentatorubral pallidoluysian atrophy is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion of a trinucleotide repeat within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.

Applications:
Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanRabbit
Concentration:
~1mg/ml
Immunogen:
The epitope recognized maps to a region between residue 1150 and the C-terminus (residue 1190) of human Atrophin 1 using the numbering given in entry NP_001007027.1 (GeneID 1822 ).
Purity:
Purified by immunoaffinity chromatography.
Form
Tris-citrate/phosphate buffer, pH 7 to 8
Specificity:
Species Crossreactivity: Human. Other species have not been tested.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.