Technical Data
A4159-07A
ATXN2L, Isoform B (Ataxin-2-like Protein, Ataxin-2 Domain Protein, Ataxin-2-related Protein, A2D, A2LG, A2LP, A2RP)
Description:
Ataxin 2 related protein isoform B is a component of a cytokine signaling cascade, having three regions similar to those of Ataxin-2, with the gene product causing familial type 2 spinocerebellar ataxia. The protein has several isoforms with different C-terminal domains, all produced from a single gene by alternative splicing. Northern blotting indicated that the gene is widely expressed in immortalized cell lines and hematopoietic and fetal tissues. The gene encoding for human Ataxin 2 related protein isoform B is localized on human chromosome 16p11. The protein is constitutively associated with cytokine receptor Mpl in vivo in human hematopoietic UT7 cells. The protein binds to the unstimulated erythropoietin receptor, whereas erythropoietin caused dissociation from the erythropoietin receptor, suggesting that the protein is a new component of the cytokine signaling system. The synthesis of the protein is greatly increased during megakaryocytic differentiation.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanRabbit
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to aa1043-1062 (DDRIPPLPPPGELKIVLAAT) of human Ataxin 2 related protein isoform B.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity:
Recognizes human ATXN2L, Isoform B.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Caroline, M. et al. J. Biol. Chem. 277:9139-9147 (2002). 2. Methia, N. et al. C. R. Acad. Sci. 318:479-482 (1995).