Technical Data
A4159-20B
ATX10 (Ataxin 10, ATXN10, ATXN-10, SCA10, SCA-10, Spinocerebellar Ataxia 10 Protein)
Description:
Ataxin-10 is a cytoplasmic protein that belongs to the family of armadillo repeat proteins. A loss of Ataxin-10 in primary neuronal cells causes increased apoptosis of cerebellar neurons. Ataxin-10 interacts with p110, an O-Linked ?-N-acetylglucosamine transferase, and may be important in the regulation of intracellular glycosylation levels and homeostasis in the brain. Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder that causes cerebellar ataxia and seizures. SCA10 is caused by an expansion of an ATTCT pentanucleotide repeat in intron 9 of the ataxin-10 gene.

Applications:
Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabAffinity Purified
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanRabbit
Concentration:
~1mg/ml
Immunogen:
The epitope recognized by this antibody maps to a region between residue 425 and 475 of human Ataxin 10 (spinocerebellar ataxia 10) using the numbering given in entry NP_037368.1 (GeneID 25814).
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in TBS, pH 7.2, 0.1% BSA, 0.1% sodium azide.
Specificity:
Species Crossreactivity: Human.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.