Technical Data
A4174-50
Aureothricin (Propionylpyrrothione, Farcinin)
500ug
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Aureothricin is an antibiotic first described by Umezawa and co-workers in Japan in 1949. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumor activity. Aureothricin is a more hydrophobic analogue of thiolutin but has received only limited attention. Members of this class, notably, thiolutin, have been shown to potent inhibitors of bacterial and yeast RNA polymerases and inhibitors of mannan and glucan formation in fungi. Studies have shown that thiolutin inhibits tumor cell-induced angiogenesis in vivo.

DMSO and DMF, partially soluble in methanol and ethanol while poorly soluble in water

CAS Number:
574-95-8

Molecular Formula:
C9H10N2O2S2

Molecular Weight:
242.32200000000000273
Source: Streptomyces sp.
Purity: > 98% by HPLC
Form: Yellow orange solid

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Studies on a common hydrolysis product of thiolutin and aureothricin. Celmer W. D. and Solomons I.A. Antibiotics Annual 1953, 622. 2. Anticancer property of dithiolopyrrolones. Webster J.M. et. al. 2000, US Patent 6,020,360. 3. Thiolutin inhibits yeast ribonucleic acid polymerases. Tipper D.J. J. Bacteriol. 1973, 116, 245. 4. Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Minamiguchi K. Int. J. Cancer 2001, 93, 307. 5. Thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Mode of action. L133 Antimicrob Agents Chemother. 1973, 3, 729.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.