Technical Data
A4189-06H
AURKA, phosphorylated (Thr288) (Serine/Threonine-protein Kinase 6, Aurora Kinase A, Aurora/IPL1-related Kinase 1, ARK-1, Aurora-related Kinase 1, hARK1, Breast Tumor-amplified Kinase, Serine/Threonine-protein Kinase 15, Serine/Threonine-protein Kinase Aur
Description:
Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.

Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry:1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
50ug-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic phosphopeptide corresponding to human AURKA around the phosphorylation site of threonine 288 (R-T-TP-L-M).
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity:
Recognizes human AURKA when phosphorylated at Thr288. Species Cross-Reactivity: mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.