Technical Data
A4447
Avermectin B1a (5-O-Demethylavermectin A1a, Antibiotic C 076B1a)
1mg
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Technical Data |
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A4447 |
Avermectin B1a (5-O-Demethylavermectin A1a, Antibiotic C 076B1a) |
1mg |
| Biochemicals | Storage: -20°CShipping: Blue Ice |
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Avermectin B1a is the major component (>80%) of the commerically available anthelmintic Abamectin (R) used to control parasitic nematodes in livestock. Avermectin B1a contains a secbutyl residue in the 24-position. In vitro and in vivo studies have shown this analogue is the more potent analogue in the commerical product. Purity: >99% by HPLC Solubility: Soluble in ethanol, methanol, DMF or DMSO. Related to: Avermectin B1b, Milbemycin A4, Milbemycin A3, Milbemycin D, Nemadectin CAS Number: 65195-55-3 Molecular Formula: C48H72O14 Molecular Weight: 873.1 |
Source: Streptomyces avermitilis Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance. Fritz L.C. et al. Proc. Natl Acad. Sci. USA 1979, 76, 2062. 2. Solubilization and characterization of a high affinity ivermectin binding site from Caenorhabditis elegans. Cully D.F. et al. Mol Pharmacol. 1991, 40, 326. 3. Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. Wolstenholme A.J. & Rogers A.T. Parasitology 2005, 131, S85-95.
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