Technical Data
A4447-01
Avermectin B1b (Antibiotic C 076B1b)
500ug
Biochemicals Storage: -20CShipping: Blue Ice
Avermectin B1b is the minor component (<20%) of the commerically available anthelmintic marketed as Abamectin(R) used to control parasitic nematodes in livestock. Avermectin B1b contains a isopropyl residue in the 24-position. In vitro and in vivo studies have shown this analogue to be active but less potent than the B1a analogue

Purity: >99% by HPLC

Solubility: Soluble in ethanol, methanol, DMF or DMSO.

Related to: Avermectin B1a, Milbemycin A4, Milbemycin A3, Milbemycin D, Nemadectin

CAS Number:
65195-56-4

Molecular Formula:
C47H70O14

Molecular Weight:
859.1
Source: Streptomyces avermitilis

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by
reducing muscle membrane resistance. Fritz L.C. et al. Proc. Natl Acad. Sci. USA 1979, 76, 2062.
2. Solubilization and characterization of a high affinity ivermectin binding site from Caenorhabditis elegans.
Cully D.F. et al. Mol Pharmacol. 1991, 40, 326.
3. Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics.
Wolstenholme A.J. & Rogers A.T. Parasitology 2005, 131, S85-95.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.