Technical Data
B0003-06B1
Bacillus anthracis (Anthrax) Toxin Receptor, Control Peptide (ATR1, TEM8, Tumor Endothelial Marker 8)
50ug
Molecular Biology Storage: -20CShipping: Blue Ice
Tumor Endothelial Marker 8 (TEM8), also called ATR1, is a glycoprotein of the anthrax toxin receptor family that is expressed by endothelial cells. Type I transmembrane isoforms of 564 aa (80-85 kD) and 368 aa (60 kD) and potentially secreted isoforms of 330 aa and 297 aa (45 kD) are differentially expressed. All diverge at the C-terminal end but share the N-terminal vWFA domain that binds the anthrax toxin PA subunit as well as collagens I and IV. Human TEM8 shares 99% aa identity with mouse and rat and 92% identity with dog and chick TEM8 within the extracellular domain.

Location:
13aa near the C-terminus of human ATR (1).

Applications:
The peptide is used for blocking the activity of ATR (CT) (TEM8) antibody. It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37C.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage, store at -20C. Aliquots are stable for at least 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity: Purified
Concentration: ~0.2mg/ml
Form: Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.02% sodium azide.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Bradley KA, Mogridge J, Mourez M, et al. Identification of the cellular receptor for anthrax toxin. Nature 2001; 414:225-9.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.