Technical Data
B0003-64M1
BAFF (B cell Activating Factor belonging to TNF Family, BLyS, TALL-1, THANK) (Biotin)
Description:
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF-and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell stimulator since it induced B cell proliferation and immunoglobulin secretion. Two receptors for BAFF were recently identified and designated TACI and BCMA. BAFF and its receptors are involved in the development of systemic lupus erythaematosus and other B cell associated autoimmune diseases. Like TNFa and TRAIL, THANK was shown to activate NF-kB and c-jun N-terminal kinase (JNK) and to induce apoptosis.

Applications:
Suitable for use in ELISA and Flow Cytometry. Other applications not tested.

Recommended Dilutions:
ELISA: Detection antibody
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG16D9Highly Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceMouseRat
Concentration:
~1mg/ml
Immunogen:
Rat RBL cells expressing mouse BAFF.
Purity:
Purified by SDS-PAGE 95%.
Form
Supplied as a liquid in PBS, 0.02% sodium azide. Labeled with Biotin.
Specificity:
Recognizes mouse BAFF.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Batten M., et al.; J. Immunol. 172, 812 (2004)