Technical Data
B0003-64P
BAFF (B cell Activating Factor belonging to TNF Family, BLyS, TALL-1, THANK)
Description:
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-eB and c-jun N-terminal kinase.

Applications:
Suitable for use in ELISA, Flow Cytometry and
Western Blot. Other applications have not been tested.

Recommended Dilutions:
ELISA: Capture
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG16D145Highly Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceMouseRat
Concentration:
~1mg/ml
Immunogen:
Rat RBL cells expressing mouse BAFF.
Purity:
Highly purified (SDS-PAGE).
Form
Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity:
Recognizes mouse BAFF.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. M. Batten, et al.; J. Immunol. 172, 812 (2004)