Technical Data
Bafilomycin C1 (Antibiotic L-681,110A1)
Biochemicals Storage: -20CShipping: Blue Ice
Bafilomycin C1 shares the same mode of action and activity as its more accessible A1 analogue Bafilomycin C1 is broadly active against bacteria, fungi, insects, nematodes and cestodes. Bafilomycin C1 has attracted interest as a potential antiosteoporotic agent in treating bone lytic diseases.The presence of the fumarate group has provided an ideal ligand for affinity chromatography of V-ATPase.

Soluble in ethanol, methanol, DMF or DMSO. NOTE: Forms methyl ketal on long term storage in methanol.

Related to:
Bafilomycin A1, Bafilomycin B1, Concanamycin A

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

CAS Number:

Molecular Formula:

Molecular Weight:
Source: Streptomyces sp.
Purity: ~95% (HPLC)

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of
osteolysis. Xu J. et al. J. Histol. Histopathol. 2007, 22, 443.
2. Bafilolides, Potent Inhibitors of the Motility and Development of the Free-Living Stages of Parasitic
Nematodes. Lacey E. et al. Int. J. Parasitol. 1995, 25, 349.
3. Purification of Vacuolar ATPase with Bafilomycin C1 Affinity Chromatography. Rautiala T.J. et al.
Biochem. Biophys. Res. Comm. 1993, 194, 50.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.